Non-communicable diseases (NCDs) are a significant public health concern in Nepal, contributing to a substantial portion of morbidity and mortality. Cardiovascular diseases (CVDs), encompassing heart disease and stroke, are a leading cause of death — in 2019 there were approximately 1,214,607 cases, resulting in 46,501 deaths, and the proportion of deaths attributable to CVDs increased from 9.77% in 1990 to 24.04% in 2019.

Cancer incidence is also rising, with common types including lung, cervical, oral, breast, stomach, and colorectal cancers; limited access to screening and diagnostic services often leads to late-stage diagnosis.

Diabetes prevalence has been increasing, driven by urbanisation, sedentary lifestyles, and unhealthy diets, with a population-based study reporting prevalence of 8.5% among adults.

Chronic respiratory diseases, including COPD and asthma, also pose a significant burden — Nepal has one of the world's highest age-adjusted death rates for chronic lung disease.

CDC-Nepal implements strategies aimed at reducing the incidence and impact of these chronic diseases, including promoting healthy lifestyles, early detection, and management of chronic conditions through community-based interventions and healthcare initiatives.